Projects
TRANSCAN VI-Quant-ALL: Automated, absolute quantification of minimal residual disease in patients with acute lymphocytic leukemia
Project description
The aims of Quant-ALL are: (1) Establishment of an amplicon based IG/TR NGS approach using single DNA copy barcoding and droplet microfluidics for IG/TR based MRD quantification in ALL. (2) Optimization of existing bioinformatics tools used for IG/TR NGS to quantify index IG/TR sequences. (3) Transfer of this technology to a pre-existing centrifugal microfluidic platform for full automation and standardization. (4) Validation of technology for childhood and adult ALL using biobanked follow-up samples that are MRD quantified with standard technologies in a reference laboratory.
Start/End of project
01.06.2019 until 31.05.2022
Project manager
Dr. Tobias Hutzenlaub (Prof. Dr. Roland Zengerle)
Contact person
Dr. Tobias Hutzenlaub
Phone:0761 203-73269
Email:tobias.hutzenlaub@imtek.uni-freiburg.de
Partners
Universitätsklinikum Schleswig-Holstein, Kiel, Deutschland / University Hospital Schleswig-Holstein, Kiel, Germany
Fondazione Tettamanti ONLUS, Italien / Fondazione Tettamanti ONLUS, Italy
ASST-PG23, Bergamo, Italien / ASST-PG23, Bergamo, Italy
CERTH, Griechenland / CERTH, Greece
Funding
BMBF
Keywords
Lab-on-a-Chip, lab-on-a-chip