Projects

Today, various bioanalytical methods are used to detect different classes of biomolecules like proteins or nucleic acids. Particular assays are designed and optimized for each class of biomolecules and are important tool in areas of application like in-vitro diagnostics, drug development or food safety. However, in these areas it is more and more important to analyze several different classes of biomolecules at once. Thus combining the capability of analyzing different classes of biomolecules like proteins and nucleic acids into one single assay would lead to a massively simplified workflow in terms of labor and time consumption as well as the use of some specialized equipment can be omitted. It would mean a substantial economic advance if protein and nucleic acid detection can be performed on one single platform. A novel concept will be investigated in this project. The innovative approach of the highly dynamic multianalyte assay will be characterized, transferred to a point-of-care platform and subsequently it will be applied for the analysis of patient samples in order to improve wound management in the clinic. The work will be conducted in close collaboration with the University Hospital Frankfurt. An improved wound management based on this analysis could facilitate fast and specific intervening in each particular case as well as a more efficient antibiotic therapy. This is of great value especially regarding the threat of antibiotic resistances.