Projects
Bioprinting of directly reprogrammed renal tubular cells for disease modelling and screening platforms (NEPHRO-PRINT)
Project description
Latest Bio-Printing technologies allow for the precise positioning of living cells in a three-dimensional arrangement supported by a simultaneously printed matrix, which enables the generation of organ-like structures in vitro. Fibroblasts (skin cells) can be directly reprogrammed into renal tubule cells (iRECs) by a novel and patented approach using four transcription factors. By combining both approaches, we aim to generate cellular tubule arrays that replicate the structure and function of the kidney tubules in vitro. The platform developed by NEPRHO-PRINT may aid drug development for kidney diseases and testing of novel substance for renal toxicity in a patient specific manner.
Start/End of project
01.10.2017 until 30.09.2020
Project manager
Dr. Stefan Zimmermann (Prof. Dr. Roland Zengerle)
Contact person
Dr. Stefan Zimmermann
Phone:+49 761 203-73283
Email:stefan.zimmermann@imtek.uni-freiburg.de
Partners
Dr. Soeren Lienkamp (Emmy-Noether-Gruppenleiter), Innere Medizin IV (Nephrologie und Allgemeinmedizin), Universitätsklinikum Freiburg
Funding
Baden-Württemberg Stiftung gGmbH
Keywords
Nierentubuluszellen, induced renal tubule cells (iRECs), direkte Reprogrammierung, Nephrologie, Nierentoxizität, Wirkstoffscreening, 3D-Bioprinting, Drop-on-demand, Extrusion, Tissue Engineering, Organ-on-Chip, Biotinte, Hydrogele, Zellbiologie, Zytokompatibität, Prozessentwicklung, induced renal tubule cells (iRECs), direct reprogramming, nephrology, nephrotoxicity, compound screening, 3D-Bio-Printing, drop-on-demand, extrusion, direct writing, tissue engineering, organ-on-chip, bio-ink, hydrogel, cytocompatibility, process development