Projects

MIB aims to develop robust, easy-to-use, and cost-effective optical methods with high sensitivity and specificity, to enable a step-change in point-of-care diagnostics of bladder cancer. The concept relies on combining optical methods – optical coherence tomography, multi-spectral opto-acoustic tomography, shifted excitation Raman difference spectroscopy, and multiphoton microscopy – providing structural, biochemical and functional information. This combination will enable in situ diagnosis of bladder cancer with superior sensitivity and specificity (96% and 50%, respectively; far superior to current cystoscopy numbers of 73% and 43%). Superior diagnosis is feasible due to unprecedented combined anatomical, biochemical and molecular tissue information, thus enabling earlier onset of treatment.